New Diagnostics Working Group E-news
(Oct 2013)
New scientific articles
Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India.
Yadav RN, Singh BK, Sharma SK, Sharma R, Soneja M, Sreenivas V, Myneedu VP, Hanif M, Kumar A, Sachdeva KS, Paramasivan CN, Vollepore B, Thakur R,Raizada N, Arora SK, Sinha S. PLoS One. 2013 Sept
Rifampicin heteroresistance in Mycobacterium tuberculosis cultures detected by phenotypic and genotypic drug susceptibility test methods.
Folkvardsen DB, Thomsen VO, Rigouts L, Rasmussen EM, Bang D, Bernaerts G, Werngren J, Toro JC, Hoffner S, Hillemann D, Svensson E. J Clin Microbiol. 2013 Sep
Bio-microfluidic platform for gold nanoprobe based DNA detection--application to Mycobacterium tuberculosis.
Bernacka-Wojcik I, Lopes P, Catarina Vaz A, Veigas B, Jerzy Wojcik P, Simões P, Barata D, Fortunato E, Viana Baptista P, Aguas H, Martins R. Biosensor and Bioelectronics 2013 Sept
Combination of multiplex PCR with denaturing high-performance liquid chromatography for rapid detection of Mycobacterium genus and simultaneous identification of the Mycobacterium tuberculosis complex.
Chen R, Gao XB, Liu ZH, Shen XB, Guo AZ, Duan YY, Liu ZL, Wu XW, Zhu DZ. Diagn Microbiol Infect Dis. 2013 Sept
Xpert MTB/RIF for diagnosis of tuberculosis and drug-resistant tuberculosis: a cost and affordability analysis.
Pantoja A, Fitzpatrick C, Vassall A, Weyer K, Floyd K. ERJ. 2013 Sept
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.
Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson SN,Chatterjee D, Fleischmann R, Alland D. Nat. Gen. 2013 Sept
Characteristics of IFN-γ responses in IGRA among pulmonary TB suspects in a TB-endemic area.
Feng JY, Huang SF, Lee MC, Ting WY, Chen YC, Lin YY, Lee YC, Su WJ. Diagn Microbiol Infect Dis. 2013 Sept
Xpert® MTB/RIF in pleural fluid for the diagnosis of tuberculosis [Short communication].
Porcel JM, Palma R, Valdés L, Bielsa S, San-José E, Esquerda A. Int J Tuberc Lung Dis. 2013 Sep
Incremental value of T-SPOT.TB for diagnosis of active pulmonary tuberculosis in children in a high-burden setting: a multivariable analysis.
Ling DI, Nicol MP, Pai M, Pienaar S, Dendukuri N, Zar HJ. Thorax. 2013 Sept
Rifampicin-resistant and rifabutin-susceptible Mycobacterium tuberculosis strains: a breakpoint artefact?
Schön T, Juréen P, Chryssanthou E, Giske CG, Kahlmeter G, Hoffner S, Angeby K. J Antimicrob Chemother. 2013 Sep
Factors influencing discordant results of the QuantiFERON-TB Gold In-tube test in patients with active TB.
Jeon YL, Nam YS, You E, Yang JJ, Kim MJ, Cho SY, Park TS, Lee HJ. J Infect. 2013 Sept
The sensitivity of an interferon-γ release assay in microbiologically confirmed pediatric tuberculosis.
Schopfer K, Rieder HL, Bodmer T, Steinlin-Schopfer JF, Chantana Y, Studer P, Laurent D, Richner B. Eur J Pediatr. 2013 Sept
Other Publications
Multidrug-resistant tuberculosis in children: evidence from global surveillance.
Zignol M, Sismanidis C, Falzon D, Glaziou P, Dara M, Floyd K. ERJ. 2013 Sept
Threat Report 2013
This report, Antibiotic resistance threats in the United States, 2013 gives a first-ever snapshot of the burden and threats posed by the antibiotic-resistant germs having the most impact on human health.
Centers for Disease Control and Prevention. 2013 Sept
Costs of tuberculosis disease in the EU – a systematic analysis and cost calculation.
Diel R, Vandeputte J, de Vries G, Stillo J, Wanlin M, Nienhaus A. ERJ. 2013 Sept
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S,Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S. Nat Genet 2013 Sept
Tuberculosis Medicines Technology and Market Landscape
UNITAID. 2013 Sept
Management of tuberculosis and HIV coinfection
The WHO Regional Office for Europe is revising five clinical protocols on treatment of and care for people with HIV and AIDS, which were part of the 13 protocols set combined in one volume in 2007. EURO WHO. 2013 Sept
Best practices in prevention, control and care for drug-resistant tuberculosis. A resource for the continued implementation of the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-Resistant Tuberculosis in the WHO European Region, 2011–2015
EURO WHO. 2013 Sept
Complex genetics of drug resistance in Mycobacterium tuberculosis.
Warner DF, Mizrahi V. Nat. Genet. 2013 Sept
Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase
CL Compton , KR. Schmitz , RT. Sauer, JK. Sello. ACS Chem Biol 2013 Sept
News
First-ever targeted roadmap outlines steps to end childhood TB deaths
Global TB leaders recently launched the Roadmap for Childhood TB: Towards Zero Deaths, which includes ten actions that, if implemented, could help save tens of thousands of children’s lives, including children infected with both TB and HIV. The actions include training and fostering leadership among health workers, actively seeking out children at risk and providing preventative therapy, and closing the funding gap for childhood TB.
UK Commits £1 Billion to the Global Fund
The UK's Secretary of State for International Development announced that the UK will contribute £1 Billion (US$1.6 billion) to the Global Fund to Fight AIDS, Tuberculosis and Malaria for the 2014-2016 period, the second-largest pledge by any government so far.
TB REACH calls for applications for fourth wave of projects
TB REACH, an initiative of the Stop TB Partnership that aims to increase the number of people with tuberculosis (TB) who are found and provided with quality care, has launched a call for applications for its fourth wave of funding.
Largest ever roll-out of GeneXpert® rapid TB test machines in 21 countries
UNITAID has invested US$ 25.9 million to purchase over 220 GeneXpert® machines and 1.4 million test cartridges for 21 countries in Africa, Eastern Europe and Asia. This is the largest ever roll-out of Xpert MTB/RIF, a diagnostic test that shortens the time to diagnose drug-resistant strains of TB from weeks to only a few hours. Co-ordinated by the World Health Organization and the Stop TB Partnership, this project – known as TBXpert– is estimated to save an additional 62,000 lives.
How much does TB cost in Europe
R. Alagna. Blog TBInnovation. 2013 Sept.
(Oct 2013)
New scientific articles
Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India.
Yadav RN, Singh BK, Sharma SK, Sharma R, Soneja M, Sreenivas V, Myneedu VP, Hanif M, Kumar A, Sachdeva KS, Paramasivan CN, Vollepore B, Thakur R,Raizada N, Arora SK, Sinha S. PLoS One. 2013 Sept
Rifampicin heteroresistance in Mycobacterium tuberculosis cultures detected by phenotypic and genotypic drug susceptibility test methods.
Folkvardsen DB, Thomsen VO, Rigouts L, Rasmussen EM, Bang D, Bernaerts G, Werngren J, Toro JC, Hoffner S, Hillemann D, Svensson E. J Clin Microbiol. 2013 Sep
Bio-microfluidic platform for gold nanoprobe based DNA detection--application to Mycobacterium tuberculosis.
Bernacka-Wojcik I, Lopes P, Catarina Vaz A, Veigas B, Jerzy Wojcik P, Simões P, Barata D, Fortunato E, Viana Baptista P, Aguas H, Martins R. Biosensor and Bioelectronics 2013 Sept
Combination of multiplex PCR with denaturing high-performance liquid chromatography for rapid detection of Mycobacterium genus and simultaneous identification of the Mycobacterium tuberculosis complex.
Chen R, Gao XB, Liu ZH, Shen XB, Guo AZ, Duan YY, Liu ZL, Wu XW, Zhu DZ. Diagn Microbiol Infect Dis. 2013 Sept
Xpert MTB/RIF for diagnosis of tuberculosis and drug-resistant tuberculosis: a cost and affordability analysis.
Pantoja A, Fitzpatrick C, Vassall A, Weyer K, Floyd K. ERJ. 2013 Sept
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.
Safi H, Lingaraju S, Amin A, Kim S, Jones M, Holmes M, McNeil M, Peterson SN,Chatterjee D, Fleischmann R, Alland D. Nat. Gen. 2013 Sept
Characteristics of IFN-γ responses in IGRA among pulmonary TB suspects in a TB-endemic area.
Feng JY, Huang SF, Lee MC, Ting WY, Chen YC, Lin YY, Lee YC, Su WJ. Diagn Microbiol Infect Dis. 2013 Sept
Xpert® MTB/RIF in pleural fluid for the diagnosis of tuberculosis [Short communication].
Porcel JM, Palma R, Valdés L, Bielsa S, San-José E, Esquerda A. Int J Tuberc Lung Dis. 2013 Sep
Incremental value of T-SPOT.TB for diagnosis of active pulmonary tuberculosis in children in a high-burden setting: a multivariable analysis.
Ling DI, Nicol MP, Pai M, Pienaar S, Dendukuri N, Zar HJ. Thorax. 2013 Sept
Rifampicin-resistant and rifabutin-susceptible Mycobacterium tuberculosis strains: a breakpoint artefact?
Schön T, Juréen P, Chryssanthou E, Giske CG, Kahlmeter G, Hoffner S, Angeby K. J Antimicrob Chemother. 2013 Sep
Factors influencing discordant results of the QuantiFERON-TB Gold In-tube test in patients with active TB.
Jeon YL, Nam YS, You E, Yang JJ, Kim MJ, Cho SY, Park TS, Lee HJ. J Infect. 2013 Sept
The sensitivity of an interferon-γ release assay in microbiologically confirmed pediatric tuberculosis.
Schopfer K, Rieder HL, Bodmer T, Steinlin-Schopfer JF, Chantana Y, Studer P, Laurent D, Richner B. Eur J Pediatr. 2013 Sept
Other Publications
Multidrug-resistant tuberculosis in children: evidence from global surveillance.
Zignol M, Sismanidis C, Falzon D, Glaziou P, Dara M, Floyd K. ERJ. 2013 Sept
Threat Report 2013
This report, Antibiotic resistance threats in the United States, 2013 gives a first-ever snapshot of the burden and threats posed by the antibiotic-resistant germs having the most impact on human health.
Centers for Disease Control and Prevention. 2013 Sept
Costs of tuberculosis disease in the EU – a systematic analysis and cost calculation.
Diel R, Vandeputte J, de Vries G, Stillo J, Wanlin M, Nienhaus A. ERJ. 2013 Sept
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S,Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S. Nat Genet 2013 Sept
Tuberculosis Medicines Technology and Market Landscape
UNITAID. 2013 Sept
Management of tuberculosis and HIV coinfection
The WHO Regional Office for Europe is revising five clinical protocols on treatment of and care for people with HIV and AIDS, which were part of the 13 protocols set combined in one volume in 2007. EURO WHO. 2013 Sept
Best practices in prevention, control and care for drug-resistant tuberculosis. A resource for the continued implementation of the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-Resistant Tuberculosis in the WHO European Region, 2011–2015
EURO WHO. 2013 Sept
Complex genetics of drug resistance in Mycobacterium tuberculosis.
Warner DF, Mizrahi V. Nat. Genet. 2013 Sept
Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase
CL Compton , KR. Schmitz , RT. Sauer, JK. Sello. ACS Chem Biol 2013 Sept
News
First-ever targeted roadmap outlines steps to end childhood TB deaths
Global TB leaders recently launched the Roadmap for Childhood TB: Towards Zero Deaths, which includes ten actions that, if implemented, could help save tens of thousands of children’s lives, including children infected with both TB and HIV. The actions include training and fostering leadership among health workers, actively seeking out children at risk and providing preventative therapy, and closing the funding gap for childhood TB.
UK Commits £1 Billion to the Global Fund
The UK's Secretary of State for International Development announced that the UK will contribute £1 Billion (US$1.6 billion) to the Global Fund to Fight AIDS, Tuberculosis and Malaria for the 2014-2016 period, the second-largest pledge by any government so far.
TB REACH calls for applications for fourth wave of projects
TB REACH, an initiative of the Stop TB Partnership that aims to increase the number of people with tuberculosis (TB) who are found and provided with quality care, has launched a call for applications for its fourth wave of funding.
Largest ever roll-out of GeneXpert® rapid TB test machines in 21 countries
UNITAID has invested US$ 25.9 million to purchase over 220 GeneXpert® machines and 1.4 million test cartridges for 21 countries in Africa, Eastern Europe and Asia. This is the largest ever roll-out of Xpert MTB/RIF, a diagnostic test that shortens the time to diagnose drug-resistant strains of TB from weeks to only a few hours. Co-ordinated by the World Health Organization and the Stop TB Partnership, this project – known as TBXpert– is estimated to save an additional 62,000 lives.
How much does TB cost in Europe
R. Alagna. Blog TBInnovation. 2013 Sept.
New Diagnostics Working Group E-news
(Sept 2013)
New scientific articles
Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF.
Weyer K, Mirzayev F, Migliori GB, Van Gemert W, D'Ambrosio L, Zignol M, Floyd K, Centis R, Cirillo DM, Tortoli E, Gilpin C, de Dieu Iragena J, Falzon D, Raviglione M. ERJ. 2013 Jul
Are peripheral microscopy centresready for next generation moleculartuberculosis diagnostics?
Denkinger CM, Nicolau I, Ramsay A, Chedore P and Pai M. ERJ 2013 Jul
Evaluation of the BD BACTEC™ MGIT™ 320 for Detection of Mycobacteria and Drug Susceptibility testing of Mycobacterium tuberculosis.
Duque A, Lin SY, Desmond E, Rienthong S, Rienthong D, Boonin C. J Clin Microbiol. 2013 Jul.
Comparison of the Xpert MTB/RIF and COBAS TaqMan MTB assays for the detection of Mycobacteriumtuberculosis in respiratory specimens.
Park KS, Kim JY, Lee JW, Hwang YY, Jeon K, Koh WJ, Ki CS, Lee NY. J Clin Microbiol. 2013 Jul
Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis
Köser CU, Bryant JM, Becq J, Török ME, Ellington MJ, Marti-Renom MA, Carmichael AJ, Parkhill J, Smith GP, Peacock SJ. N Engl J Med. 2013 Jul
Inconsistent Results with the Xpert-MTB/Rif Assay in Detection of Mycobacterium tuberculosis with an rpoB Mutation Associated with Low Level of Rifampin Resistance: Diagnostic Implications
Somoskovi A, Deggim V, Ciardo D, Bloemberg GV. J Clin Microbiol. 2013 Jul
Simple, direct drug susceptibility testing technique for diagnosis of drug-resistant tuberculosis in resource-poor settings.
Kim CK, Joo YT, Lee EP, Park YK, Kim HJ, Kim SJ. Int J Tuberc Lung Dis. 2013 Jul
Challenges in Evaluating the Cost-effectiveness of New Diagnostic Tests for HIV-Associated Tuberculosis.
Andrews JR, Lawn SD, Dowdy DW, Walensky RP. Clin Infect Dis. 2013 Jul
Evaluation of Xpert MTB/RIF for Detection of Tuberculosis from Blood Samples of HIV-Infected Adults Confirms Mycobacterium tuberculosis Bacteremia as an Indicator of Poor Prognosis.
Feasey NA, Banada PP, Howson W, Sloan DJ, Mdolo A, Boehme C, Chipungu GA, Allain TJ, Heyderman RS, Corbett EL, Alland D. J Clin Microbiol. 2013 Jul
Rapid method for Mycobacterium tuberculosis identification using electrospray ionization tandem mass spectrometry analysis of mycolic acids.
Szewczyk R, Kowalski K, Janiszewska-Drobinska B, Druszczyńska M. Diagn Microbiol Infect Dis. 2013 Jul
Use of Colorimetric Culture Methods for Detection of Mycobacterium tuberculosis Complex Isolates from Sputum Samples in Resource-Limited Settings.
Boum Y 2nd, Orikiriza P, Rojas-Ponce G, Riera-Montes M, Atwine D, Nansumba M, Bazira J, Tuyakira E, De Beaudrap P, Bonnet M, Page AL. J Clin Microbiol. 2013 Jul
Integrating the Xpert MTB/RIF Assay into a Diagnostic Workflow for Rapid Detection of Mycobacteriumtuberculosis in a Low-Prevalence Area.
Deggim V, Somoskovi A, Voit A, Böttger EC, Bloemberg GV. J Clin Microbiol. 2013 Jul
Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective study.
Prof Heather J Zar PhD, Lesley Workman MPH, Washiefa Isaacs MSc, Prof Keertan Dheda PhD, Widaad Zemanay PhD, Prof Mark P Nicol PhD. Lancet GH. 2013 Jul
Key publications
Domestic and donor financing for tuberculosis care and control in low-income and middle-income countries: an analysis of trends, 2002—11, and requirements to meet 2015 targets.
Katherine Floyd PhD, Christopher Fitzpatrick MSc, Andrea Pantoja MSc, Mario Raviglione MD. Lancet. 2013 Jul
Universal access to care for multidrug-resistant tuberculosis: an analysis of surveillance data.
Dennis Falzon, Ernesto Jaramillo, Fraser Wares, Matteo Zignol, Katherine Floyd, Mario C Raviglione. Lancet. 2013 Jul
Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA.
Sherry Xi Chen, David Yu Zhang, Georg Seelig. Nat Chem. 2013 Jul
Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity.
Fan Zhang, Ying-Jie Lu, and Richard Malley. PNAS. 2013 Jul
News
GeneXpert MTBRif, three years after endorsement.
TBInnovation- Riccardo Alagna
Otsuka Receives Opinion from CHMP on Delamanid.
Wall street Journal
Questions and answers on the refusal of the marketing authorisation for Delamanid.
European Medicine Agency
FDA permits marketing of first U.S. test labeled for simultaneous detection of tuberculosis bacteria and resistance to the antibiotic rifampin.
FDA NEWS RELEASE
(Sept 2013)
New scientific articles
Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF.
Weyer K, Mirzayev F, Migliori GB, Van Gemert W, D'Ambrosio L, Zignol M, Floyd K, Centis R, Cirillo DM, Tortoli E, Gilpin C, de Dieu Iragena J, Falzon D, Raviglione M. ERJ. 2013 Jul
Are peripheral microscopy centresready for next generation moleculartuberculosis diagnostics?
Denkinger CM, Nicolau I, Ramsay A, Chedore P and Pai M. ERJ 2013 Jul
Evaluation of the BD BACTEC™ MGIT™ 320 for Detection of Mycobacteria and Drug Susceptibility testing of Mycobacterium tuberculosis.
Duque A, Lin SY, Desmond E, Rienthong S, Rienthong D, Boonin C. J Clin Microbiol. 2013 Jul.
Comparison of the Xpert MTB/RIF and COBAS TaqMan MTB assays for the detection of Mycobacteriumtuberculosis in respiratory specimens.
Park KS, Kim JY, Lee JW, Hwang YY, Jeon K, Koh WJ, Ki CS, Lee NY. J Clin Microbiol. 2013 Jul
Whole-genome sequencing for rapid susceptibility testing of M. tuberculosis
Köser CU, Bryant JM, Becq J, Török ME, Ellington MJ, Marti-Renom MA, Carmichael AJ, Parkhill J, Smith GP, Peacock SJ. N Engl J Med. 2013 Jul
Inconsistent Results with the Xpert-MTB/Rif Assay in Detection of Mycobacterium tuberculosis with an rpoB Mutation Associated with Low Level of Rifampin Resistance: Diagnostic Implications
Somoskovi A, Deggim V, Ciardo D, Bloemberg GV. J Clin Microbiol. 2013 Jul
Simple, direct drug susceptibility testing technique for diagnosis of drug-resistant tuberculosis in resource-poor settings.
Kim CK, Joo YT, Lee EP, Park YK, Kim HJ, Kim SJ. Int J Tuberc Lung Dis. 2013 Jul
Challenges in Evaluating the Cost-effectiveness of New Diagnostic Tests for HIV-Associated Tuberculosis.
Andrews JR, Lawn SD, Dowdy DW, Walensky RP. Clin Infect Dis. 2013 Jul
Evaluation of Xpert MTB/RIF for Detection of Tuberculosis from Blood Samples of HIV-Infected Adults Confirms Mycobacterium tuberculosis Bacteremia as an Indicator of Poor Prognosis.
Feasey NA, Banada PP, Howson W, Sloan DJ, Mdolo A, Boehme C, Chipungu GA, Allain TJ, Heyderman RS, Corbett EL, Alland D. J Clin Microbiol. 2013 Jul
Rapid method for Mycobacterium tuberculosis identification using electrospray ionization tandem mass spectrometry analysis of mycolic acids.
Szewczyk R, Kowalski K, Janiszewska-Drobinska B, Druszczyńska M. Diagn Microbiol Infect Dis. 2013 Jul
Use of Colorimetric Culture Methods for Detection of Mycobacterium tuberculosis Complex Isolates from Sputum Samples in Resource-Limited Settings.
Boum Y 2nd, Orikiriza P, Rojas-Ponce G, Riera-Montes M, Atwine D, Nansumba M, Bazira J, Tuyakira E, De Beaudrap P, Bonnet M, Page AL. J Clin Microbiol. 2013 Jul
Integrating the Xpert MTB/RIF Assay into a Diagnostic Workflow for Rapid Detection of Mycobacteriumtuberculosis in a Low-Prevalence Area.
Deggim V, Somoskovi A, Voit A, Böttger EC, Bloemberg GV. J Clin Microbiol. 2013 Jul
Rapid diagnosis of pulmonary tuberculosis in African children in a primary care setting by use of Xpert MTB/RIF on respiratory specimens: a prospective study.
Prof Heather J Zar PhD, Lesley Workman MPH, Washiefa Isaacs MSc, Prof Keertan Dheda PhD, Widaad Zemanay PhD, Prof Mark P Nicol PhD. Lancet GH. 2013 Jul
Key publications
Domestic and donor financing for tuberculosis care and control in low-income and middle-income countries: an analysis of trends, 2002—11, and requirements to meet 2015 targets.
Katherine Floyd PhD, Christopher Fitzpatrick MSc, Andrea Pantoja MSc, Mario Raviglione MD. Lancet. 2013 Jul
Universal access to care for multidrug-resistant tuberculosis: an analysis of surveillance data.
Dennis Falzon, Ernesto Jaramillo, Fraser Wares, Matteo Zignol, Katherine Floyd, Mario C Raviglione. Lancet. 2013 Jul
Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA.
Sherry Xi Chen, David Yu Zhang, Georg Seelig. Nat Chem. 2013 Jul
Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity.
Fan Zhang, Ying-Jie Lu, and Richard Malley. PNAS. 2013 Jul
News
GeneXpert MTBRif, three years after endorsement.
TBInnovation- Riccardo Alagna
Otsuka Receives Opinion from CHMP on Delamanid.
Wall street Journal
Questions and answers on the refusal of the marketing authorisation for Delamanid.
European Medicine Agency
FDA permits marketing of first U.S. test labeled for simultaneous detection of tuberculosis bacteria and resistance to the antibiotic rifampin.
FDA NEWS RELEASE
New Diagnostics Working Group E-news
(July 2013)
Publications (New scientific articles)
Rifampicin resistance missed in automated liquid culture system for mycobacterium tuberculosis with specific rpob-mutations.
Leen Rigouts, Mourad Gumusboga, Willem Bram de Rijk, Elie Nduwamahoro, Cécile Uwizeye, Bouke de Jong and Armand Van Deun J Clin Microbiol. 2013
Rifampicin drug resistance tests for tuberculosis: challenging the gold standard.
Van Deun A, Maug AK, Bola V, Lebeke R, Hossain MA, de Rijk WB, Rigouts L, Gumusboga A, Torrea G, de Jong BC. J Clin Microbiol. 2013
Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.
Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM. Nat Genet. 2013
The Health-System Benefits and Cost-effectiveness of Using Mycobacterium Tuberculosis Direct Nucleic Acid Amplification Testing to Diagnose Tuberculosis Disease in the United States.
Marks SM, Cronin W, Venkatappa T, Maltas G, Chon S, Sharnprapai S, Gaeddert M, Tapia J, Dorman SE, Etkind S, Crosby C, Blumberg HM, Bernardo. J. Clin Infect Dis. 2013
Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Shuo Zhang, Jiazhen Chen, Wanliang Shi, Wei Liu, Wenhong Zhang and Ying Zhang. Nature. 2013
Quantiferon to diagnose infection by Mycobacterium tuberculosis: Performance in infants and older children.
Blandinières A, de Lauzanne A, Guérin-El Khourouj V, Gourgouillon N, See H, Pédron B, Faye A, Sterkers G. J Infect. 2013
Challenges in evaluating the cost-effectiveness of new diagnostics for HIV-associated tuberculosis.
Andrews JR, Lawn SD, Dowdy DW, Walensky RP. Clin Infect Dis. 2013
Key pubblications
WHO interim guidance launched on the use of bedaquiline to treat MDR-TB
For the first time in over 40 years, a new TB drug with a novel mechanism of action - bedaquiline- is available, and was granted accelerated approval by the United States Food and Drug Administration in December 2012
Systematic screening for active tuberculosis: principles and recommendations
WHO has developed guidelines on systematic screening for active tuberculosis (TB) based on a thorough review of available evidence
News
A new global partnership: eradicate poverty and transform economies through sustainable development
TB made it in the Report of the High-Level Panel of Eminent Persons on the Post-2015 Development Agenda
Mobile initiative aims to combat tuberculosis in Western Ghana
The IOM team will use a mobile TB diagnostic van equipped with a GeneXpert MTB/RIF machine to reach at least 317,000 individuals in the Western Region of Ghana.
(July 2013)
Publications (New scientific articles)
Rifampicin resistance missed in automated liquid culture system for mycobacterium tuberculosis with specific rpob-mutations.
Leen Rigouts, Mourad Gumusboga, Willem Bram de Rijk, Elie Nduwamahoro, Cécile Uwizeye, Bouke de Jong and Armand Van Deun J Clin Microbiol. 2013
Rifampicin drug resistance tests for tuberculosis: challenging the gold standard.
Van Deun A, Maug AK, Bola V, Lebeke R, Hossain MA, de Rijk WB, Rigouts L, Gumusboga A, Torrea G, de Jong BC. J Clin Microbiol. 2013
Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis.
Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM. Nat Genet. 2013
The Health-System Benefits and Cost-effectiveness of Using Mycobacterium Tuberculosis Direct Nucleic Acid Amplification Testing to Diagnose Tuberculosis Disease in the United States.
Marks SM, Cronin W, Venkatappa T, Maltas G, Chon S, Sharnprapai S, Gaeddert M, Tapia J, Dorman SE, Etkind S, Crosby C, Blumberg HM, Bernardo. J. Clin Infect Dis. 2013
Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Shuo Zhang, Jiazhen Chen, Wanliang Shi, Wei Liu, Wenhong Zhang and Ying Zhang. Nature. 2013
Quantiferon to diagnose infection by Mycobacterium tuberculosis: Performance in infants and older children.
Blandinières A, de Lauzanne A, Guérin-El Khourouj V, Gourgouillon N, See H, Pédron B, Faye A, Sterkers G. J Infect. 2013
Challenges in evaluating the cost-effectiveness of new diagnostics for HIV-associated tuberculosis.
Andrews JR, Lawn SD, Dowdy DW, Walensky RP. Clin Infect Dis. 2013
Key pubblications
WHO interim guidance launched on the use of bedaquiline to treat MDR-TB
For the first time in over 40 years, a new TB drug with a novel mechanism of action - bedaquiline- is available, and was granted accelerated approval by the United States Food and Drug Administration in December 2012
Systematic screening for active tuberculosis: principles and recommendations
WHO has developed guidelines on systematic screening for active tuberculosis (TB) based on a thorough review of available evidence
News
A new global partnership: eradicate poverty and transform economies through sustainable development
TB made it in the Report of the High-Level Panel of Eminent Persons on the Post-2015 Development Agenda
Mobile initiative aims to combat tuberculosis in Western Ghana
The IOM team will use a mobile TB diagnostic van equipped with a GeneXpert MTB/RIF machine to reach at least 317,000 individuals in the Western Region of Ghana.
